Effects of acute stress on cardiac endocannabinoids, lipogenesis, and inflammation in rats.

ABSTRACT:

Objective

Trauma exposure can precipitate acute stress (AS) and cardiovascular disorders (CVD). Identifying AS-related physiologic changes that affect CVD risk could inform development of early CVD prevention strategies. The endocannabinoid system (ECS) regulates hypothalamic-pituitary-adrenal axis and stress-related cardiovascular function. We examine stress-related ECS activity and its association with cardiovascular biochemistry/function after AS.

Methods

Rodents (n = 8-16/group) were exposed to predator odor or saline; elevated plus maze, blood pressure, serum and cardiac ECS markers, and lipid metabolism were assessed 24 hours and 2 weeks postexposure.

Results

At 24 hours, the predator odor group demonstrated anxiety-like behavior and had a) elevated serum marker

SUBMITTER: Holman EA 

PROVIDER: S-EPMC3988664 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature