The effects of acute nicotine, chronic nicotine, and withdrawal from chronic nicotine on performance of a cued appetitive response.

ABSTRACT: Nicotine is a widely used addictive drug, with an estimated 73 million Americans 12 years of age or older having used a tobacco product in the last month, despite documented risks to personal health. Nicotine alters cognitive processes, which include effects on attention and impulsivity, a mechanism that may contribute to the addictive properties of the drug. Individuals with a variety of psychological disorders ranging from attention deficit hyperactivity disorder (ADHD) to schizophrenia smoke at a higher rate than the rest of the population and show deficits in impulse control. The present studies evaluated the effects of acute, chronic, and withdrawal from chronic nicotine on an operant task that measured premature and signaled nose pokes, as well as performance efficiency in C57BL/6J m

SUBMITTER: Leach PT 

PROVIDER: S-EPMC3988695 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature