Transcriptional consequences of schizophrenia candidate miR-137 manipulation in human neural progenitor cells.

ABSTRACT: MIR137, transcribed as the microRNA miR-137, is one of the leading candidate schizophrenia susceptibility genes to arise from large genome-wide association studies (GWAS) of the disorder. Recent data suggest that miR-137 modulates the expression of other schizophrenia susceptibility genes. Although bioinformatic resources are available with which to predict genes regulated by individual microRNA, there has been a lack of empirical data on genome-wide gene expression changes following miR-137 manipulation. We have therefore performed a genome-wide assessment of transcriptional changes in a human neural progenitor cell line after miR-137 over-expression and inhibition in order to elucidate molecular pathways by which genetic perturbation of miR-137 could promote susceptibility to schizophren

SUBMITTER: Hill MJ 

PROVIDER: S-EPMC3988999 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature