Altered orbitofrontal sulcogyral patterns in adult males with high-functioning autism spectrum disorders.

ABSTRACT: Functions of the orbitofrontal cortex include diverse social, cognitive and affective processes, many of which are abnormal in autism spectrum disorders (ASDs). Recently, altered orbitofrontal sulcogyral patterns have been revealed in several psychiatric conditions, such as schizophrenia, indicating a possibility that altered orbitofrontal sulcogyral morphology reflects abnormal neurodevelopment. However, the presence of sulcal alterations in ASD remains unexplored. Using structural magnetic resonance imaging, subtypes of the 'H-shaped' sulcus (Type I, II and III, in order of frequency), posterior orbital sulcus (POS) and intermediate orbital sulcus were identified in each hemisphere of adult males with ASD (n = 51) and matched normal controls (n = 55) based on the study by Chiavaras and P

SUBMITTER: Watanabe H 

PROVIDER: S-EPMC3989135 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature