A meta analysis of pancreatic microarray datasets yields new targets as cancer genes and biomarkers.

ABSTRACT: The lack of specific symptoms at early tumor stages, together with a high biological aggressiveness of the tumor contribute to the high mortality rate for pancreatic cancer (PC), which has a five year survival rate of less than 5%. Improved screening for earlier diagnosis, through the detection of diagnostic and prognostic biomarkers provides the best hope of increasing the rate of curatively resectable carcinomas. Though many serum markers have been reported to be elevated in patients with PC, so far, most of these markers have not been implemented into clinical routine due to low sensitivity or specificity. In this study, we have identified genes that are significantly upregulated in PC, through a meta-analysis of large number of microarray datasets. We demonstrate that the biological fu

SUBMITTER: Goonesekere NC 

PROVIDER: S-EPMC3989178 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature