Human immune responses to H. pylori HLA Class II epitopes identified by immunoinformatic methods.

ABSTRACT: H. pylori persists in the human stomach over decades and promotes several adverse clinical sequelae including gastritis, peptic ulcers and gastric cancer that are linked to the induction and subsequent evasion of chronic gastric inflammation. Emerging evidence indicates that H. pylori infection may also protect against asthma and some other immune-mediated conditions through regulatory T cell effects outside the stomach. To characterize the complexity of the CD4+ T cell response generated during H. pylori infection, computational methods were previously used to generate a panel of 90 predicted epitopes conserved among H. pylori genomes that broadly cover HLA Class II diversity for maximum population coverage. Here, these sequences were tested individually for their ability to induce in vit

SUBMITTER: Zhang S 

PROVIDER: S-EPMC3989244 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature