Dataset Information

Association of CASQ2 polymorphisms with sudden cardiac arrest and heart failure in patients with coronary artery disease.

ABSTRACT:

Background

Abnormal calcium handling plays a crucial role in arrhythmias, sudden cardiac arrest (SCA), and congestive heart failure (CHF). Calsequestrin 2 (CASQ2) mutations affect calcium release and initiate malignant ventricular arrhythmias (VAs) and SCA syndromes. Common single nucleotide polymorphisms (SNPs) in CASQ2 may be associated with SCA in patients with coronary artery disease (CAD).

Objective

The purpose of this study was to examine the association of common CASQ2 SNPs with the risk of SCA in patients with CAD.

Methods

CASQ2 SNPs (n = 14) were genotyped and analyzed in a case control study comparing 114 patients with CAD and SCA due to VA to 311 CAD controls without VA or SCA.