Investigation of maternal genotype effects in autism by genome-wide association.

ABSTRACT: Like most psychiatric disorders, autism spectrum disorders have both a genetic and an environmental component. While previous studies have clearly demonstrated the contribution of in utero (prenatal) environment on autism risk, most of them focused on transient environmental factors. Based on a recent sibling study, we hypothesized that environmental factors could also come from the maternal genome, which would result in persistent effects across siblings. In this study, the possibility of maternal genotype effects was examined by looking for common variants (single-nucleotide polymorphisms or SNPs) in the maternal genome associated with increased risk of autism in children. A case/control genome-wide association study was performed using mothers of probands as cases, and either fathers of

SUBMITTER: Yuan H 

PROVIDER: S-EPMC3989385 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature