Longitudinal study of recurrent metastatic melanoma cell lines underscores the individuality of cancer biology.

ABSTRACT: Recurrent metastatic melanoma provides a unique opportunity to analyze disease evolution in metastatic cancer. Here, we followed up eight patients with an unusually prolonged history of metastatic melanoma, who developed a total of 26 recurrences over several years. Cell lines derived from each metastasis were analyzed by comparative genomic hybridization and global transcript analysis. We observed that conserved, patient-specific characteristics remain stable in recurrent metastatic melanoma even after years and several recurrences. Differences among individual patients exceeded within-patient lesion variability, both at the DNA copy number (P<0.001) and RNA gene expression level (P<0.001). Conserved patient-specific traits included expression of several cancer/testis antigens and the c-k

SUBMITTER: Pos Z 

PROVIDER: S-EPMC3989423 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature