WWC1 genotype modulates age-related decline in episodic memory function across the adult life span.

ABSTRACT:

Background

Episodic memory (EM) declines with age and the rate of decline is variable across individuals. A single nucleotide polymorphism (rs17070145) in the WWC1 gene that encodes the KIBRA protein critical for long-term potentiation and memory consolidation has previously been associated with EM performance, as well as differences in hippocampal engagement during EM tasks using functional magnetic resonance imaging (fMRI). In the current study, we explore the effect of this polymorphism on EM-related activity and cognitive performance across the adult life span using fMRI.

Methods

Two hundred thirty-two healthy, Caucasian subjects (18-89 years) completed a battery of cognitive tests, as well as an EM task during an fMRI scan.

Results

WWC1 T carriers had significant

SUBMITTER: Muse J 

PROVIDER: S-EPMC3989426 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature