Ontology highlight
ABSTRACT:
SUBMITTER: Kennedy-Nasser AA
PROVIDER: S-EPMC3989436 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Clinical cancer research : an official journal of the American Association for Cancer Research 20140226 8
<h4>Purpose</h4>GVHD after allogeneic hematopoietic stem cell transplantation (alloSCT) has been associated with low numbers of circulating CD4(+)CD25(+)FoxP3(+) regulatory T cells (Tregs). Because Tregs express high levels of the interleukin (IL)-2 receptor, they may selectively expand in vivo in response to doses of IL-2 insufficient to stimulate T effector T-cell populations, thereby preventing GVHD.<h4>Experimental design</h4>We prospectively evaluated the effects of ultra low-dose (ULD) IL- ...[more]