EGFR controls IQGAP basolateral membrane localization and mitotic spindle orientation during epithelial morphogenesis.

ABSTRACT: Establishing the correct orientation of the mitotic spindle is an essential step in epithelial cell division in order to ensure that epithelial tubules form correctly during organ development and regeneration. While recent findings have identified some of the molecular mechanisms that underlie spindle orientation, many aspects of this process remain poorly understood. Here, we have used the 3D-MDCK model system to demonstrate a key role for a newly identified protein complex formed by IQGAP1 and the epithelial growth factor receptor (EGFR) in controlling the orientation of the mitotic spindle. IQGAP1 is a scaffolding protein that regulates many cellular pathways, from cell-cell adhesion to microtubule organization, and its localization in the basolateral membrane ensures correct spindle or

SUBMITTER: Banon-Rodriguez I 

PROVIDER: S-EPMC3989607 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature