Sex differences in remifentanil requirements for preventing cough during anesthetic emergence.

ABSTRACT:

Purpose

Target-controlled infusion (TCI) of remifentanil can suppress coughing during emergence from general anesthesia; nevertheless, previous studies under different clinical conditions recommend significantly different effective effect-site concentrations (effective Ce) of remifentanil for 50% of patients (EC₅₀). The differences among these studies include type of surgery and patient sex. In recent years, study of sex differences in regards to anesthetic pharmacology has drawn greater interest. Accordingly, we attempted to determine the effective Ce of remifentanil for preventing cough for each sex under the same clinical conditions.

Materials and methods

Twenty female and 25 male ASA physical status I-II grade patients between the ages of 20 and 46 years who were undergo

SUBMITTER: Soh S 

PROVIDER: S-EPMC3990090 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature