The long-term effects of conventional and atypical antipsychotics in patients with probable Alzheimer's disease.

ABSTRACT:

Objective

The authors sought to determine the effects of conventional and atypical antipsychotic use on time to nursing home admission and time to death in a group of outpatients with mild to moderate probable Alzheimer's disease.

Method

The authors examined time to nursing home admission and time to death in 957 patients with the diagnosis of probable Alzheimer's disease who had at least one follow-up evaluation (mean follow-up time, 4.3 years [SD=2.7]; range, 0.78-18.0 years) using Cox proportional hazard models adjusted for age, gender, education level, dementia severity, hypertension, diabetes mellitus, heart disease, extrapyramidal signs, depression, psychosis, aggression, agitation, and dementia medication use.

Results

A total of 241 patients (25%) were exposed

SUBMITTER: Lopez OL 

PROVIDER: S-EPMC3990263 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature