Expression quantitative trait analyses to identify causal genetic variants for type 2 diabetes susceptibility.

ABSTRACT: Type 2 diabetes (T2D) is a common metabolic disorder which is caused by multiple genetic perturbations affecting different biological pathways. Identifying genetic factors modulating the susceptibility of this complex heterogeneous metabolic phenotype in different ethnic and racial groups remains challenging. Despite recent success, the functional role of the T2D susceptibility variants implicated by genome-wide association studies (GWAS) remains largely unknown. Genetic dissection of transcript abundance or expression quantitative trait (eQTL) analysis unravels the genomic architecture of regulatory variants. Availability of eQTL information from tissues relevant for glucose homeostasis in humans opens a new avenue to prioritize GWAS-implicated variants that may be involved in triggering

SUBMITTER: Das SK 

PROVIDER: S-EPMC3990322 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature