Comparison of four methods of analysis of lipoprotein particle subfractions for their association with angiographic progression of coronary artery disease.

ABSTRACT:

Background

Compare gradient gel electrophoresis (GGE), vertical auto profile ultracentrifugation (VAP-II), nuclear magnetic resonance spectroscopy (NMR), and ion mobility for their ability to relate low- (LDL), intermediate- (IDL), very-low-density (VLDL) and high-density lipoprotein (HDL) subfraction concentrations to atherosclerotic progression.

Methods and results

Regression analyses of 136 patients who received baseline and follow-up coronary angiographies and subfraction measurements by all four methods in the HDL Atherosclerosis Treatment Study. Prior analyses have shown that the intervention primarily affected disease progression in proximal arteries with <30% stenoses at baseline. Three-year increases in percent stenoses were consistently associated with higher on-st

SUBMITTER: Williams PT 

PROVIDER: S-EPMC3990359 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature