Oxidative stress and its downstream signaling in aging eyes.

ABSTRACT:

Background

Oxidative stress (OS) and its biomarkers are the biochemical end point of the imbalance between reactive oxygen species (ROS) production and the ability of the antioxidant (AOX) biological systems to fight against oxidative injury.

Objective

We reviewed the role of OS and its downstream signaling in aging eyes.

Methods

A search of the literature and current knowledge on the physiological and pathological mechanisms of OS were revisited in relation to the eyes and the aging process. Most prevalent ocular diseases have been analyzed herein in relation to OS and nutraceutic supplements, such as dry-eye disorders, glaucoma, age-related macular degeneration, and diabetic retinopathy.

Results

Clinical, biochemical, and molecular data from anterior and post

SUBMITTER: Pinazo-Duran MD 

PROVIDER: S-EPMC3990383 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature