Physical activity and prostate gene expression in men with low-risk prostate cancer.

ABSTRACT:

Purpose

Vigorous physical activity after diagnosis of localized prostate cancer may reduce the risk of disease progression and prostate cancer-specific mortality. The molecular mechanisms by which physical activity may exert protective effects in the prostate remain unknown.

Methods

We examined the associations between self-reported physical activity and gene expression patterns in morphologically normal prostate tissue of 71 men with low-risk prostate cancer on active surveillance. Differential gene expression, gene set, and pathway analyses were conducted comparing dichotomous groups defined by type, intensity, and amount of physical activity reported.

Results

Cell cycling and DNA repair pathways were up-regulated in men who participated in ≥ 3 h/week vigorous activ

SUBMITTER: Magbanua MJ 

PROVIDER: S-EPMC3990413 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature