Vectored immunoprophylaxis protects humanized mice from mucosal HIV transmission.

ABSTRACT: The vast majority of new HIV infections result from relatively inefficient transmission of the virus across mucosal surfaces during sexual intercourse. A consequence of this inefficiency is that small numbers of transmitted founder viruses initiate most heterosexual infections. This natural bottleneck to transmission has stimulated efforts to develop interventions that are aimed at blocking this step of the infection process. Despite the promise of this strategy, clinical trials of preexposure prophylaxis have had limited degrees of success in humans, in part because of lack of adherence to the recommended preexposure treatment regimens. In contrast, a number of existing vaccines elicit systemic immunity that protects against mucosal infections, such as the vaccines for influenza and human

SUBMITTER: Balazs AB 

PROVIDER: S-EPMC3990417 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature