A synergism between adaptive effects and evolvability drives whole genome duplication to fixation.

ABSTRACT: Whole genome duplication has shaped eukaryotic evolutionary history and has been associated with drastic environmental change and species radiation. While the most common fate of WGD duplicates is a return to single copy, retained duplicates have been found enriched for highly interacting genes. This pattern has been explained by a neutral process of subfunctionalization and more recently, dosage balance selection. However, much about the relationship between environmental change, WGD and adaptation remains unknown. Here, we study the duplicate retention pattern postWGD, by letting virtual cells adapt to environmental changes. The virtual cells have structured genomes that encode a regulatory network and simple metabolism. Populations are under selection for homeostasis and evolve by point

SUBMITTER: Cuypers TD 

PROVIDER: S-EPMC3990473 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature