Timing of neuropeptide coupling determines synchrony and entrainment in the mammalian circadian clock.

ABSTRACT: Robust synchronization is a critical feature of several systems including the mammalian circadian clock. The master circadian clock in mammals consists of about 20000 'sloppy' neuronal oscillators within the hypothalamus that keep robust time by synchronization driven by inter-neuronal coupling. The complete understanding of this synchronization in the mammalian circadian clock and the mechanisms underlying it remain an open question. Experiments and computational studies have shown that coupling individual oscillators can achieve robust synchrony, despite heterogeneity and different network topologies. But, much less is known regarding the mechanisms and circuits involved in achieving this coupling, due to both system complexity and experimental limitations. Here, we computationally study

SUBMITTER: Ananthasubramaniam B 

PROVIDER: S-EPMC3990482 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature