Experimental infection of rhesus macaques and common marmosets with a European strain of West Nile virus.

ABSTRACT: West Nile virus (WNV) is a mosquito-borne flavivirus that infects humans and other mammals. In some cases WNV causes severe neurological disease. During recent years, outbreaks of WNV are increasing in worldwide distribution and novel genetic variants of the virus have been detected. Although a substantial amount of data exists on WNV infections in rodent models, little is known about early events during WNV infection in primates, including humans. To gain a deeper understanding of this process, we performed experimental infections of rhesus macaques and common marmosets with a virulent European WNV strain (WNV-Ita09) and monitored virological, hematological, and biochemical parameters. WNV-Ita09 productively infected both monkey species, with higher replication and wider tissue distributi

SUBMITTER: Verstrepen BE 

PROVIDER: S-EPMC3990483 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature