Impact of different oseltamivir regimens on treating influenza A virus infection and resistance emergence: insights from a modelling study.

ABSTRACT: Several studies have proven oseltamivir to be efficient in reducing influenza viral titer and symptom intensity. However, the usefulness of oseltamivir can be compromised by the emergence and spread of drug-resistant virus. The selective pressure exerted by different oseltamivir therapy regimens have received little attention. Combining models of drug pharmacokinetics, pharmacodynamics, viral kinetics and symptom dynamics, we explored the efficacy of oseltamivir in reducing both symptoms (symptom efficacy) and viral load (virological efficacy). We simulated samples of 1000 subjects using previously estimated between-subject variability in viral and symptom dynamic parameters to describe the observed heterogeneity in a patient population. We simulated random mutations conferring resistance

SUBMITTER: Canini L 

PROVIDER: S-EPMC3990489 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature