Phylodynamic inference for structured epidemiological models.

ABSTRACT: Coalescent theory is routinely used to estimate past population dynamics and demographic parameters from genealogies. While early work in coalescent theory only considered simple demographic models, advances in theory have allowed for increasingly complex demographic scenarios to be considered. The success of this approach has lead to coalescent-based inference methods being applied to populations with rapidly changing population dynamics, including pathogens like RNA viruses. However, fitting epidemiological models to genealogies via coalescent models remains a challenging task, because pathogen populations often exhibit complex, nonlinear dynamics and are structured by multiple factors. Moreover, it often becomes necessary to consider stochastic variation in population dynamics when fitt

SUBMITTER: Rasmussen DA 

PROVIDER: S-EPMC3990497 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature