Genome-wide diet-gene interaction analyses for risk of colorectal cancer.

ABSTRACT: Dietary factors, including meat, fruits, vegetables and fiber, are associated with colorectal cancer; however, there is limited information as to whether these dietary factors interact with genetic variants to modify risk of colorectal cancer. We tested interactions between these dietary factors and approximately 2.7 million genetic variants for colorectal cancer risk among 9,287 cases and 9,117 controls from ten studies. We used logistic regression to investigate multiplicative gene-diet interactions, as well as our recently developed Cocktail method that involves a screening step based on marginal associations and gene-diet correlations and a testing step for multiplicative interactions, while correcting for multiple testing using weighted hypothesis testing. Per quartile increment in th

SUBMITTER: Figueiredo JC 

PROVIDER: S-EPMC3990510 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature