Review of the clinical and biologic aspects of human papillomavirus-positive squamous cell carcinomas of the head and neck.

ABSTRACT: Human papillomavirus (HPV), a known etiology of a subset of head-and-neck squamous cell carcinomas (HNCs), causes numerous alterations in normal cellular functions. This article reviews the biology, detection, and treatment of HPV-positive HNC. The role of HPV oncoproteins in tumor development, the natural history of HPV infection, and risk factors for and prevention of transmission of oral HPV are considered. Commonly used methods for detecting HPV infection, including limitations of these methods, are discussed to aid the practicing clinician in using these tests in their clinical practice. Clinical characteristics of HPV-positive HNC, including potential explanations for the improved outcomes seen in patients with HPV-positive HNC, are assessed. Ongoing clinical trials specific for pati

SUBMITTER: Blitzer GC 

PROVIDER: S-EPMC3990872 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature