Interaction between serum BDNF and aerobic fitness predicts recognition memory in healthy young adults.

ABSTRACT: Convergent evidence from human and non-human animal studies suggests aerobic exercise and increased aerobic capacity may be beneficial for brain health and cognition. It is thought growth factors may mediate this putative relationship, particularly by augmenting plasticity mechanisms in the hippocampus, a brain region critical for learning and memory. Among these factors, glucocorticoids, brain derived neurotrophic factor (BDNF), insulin-like growth factor-1 (IGF-1), and vascular endothelial growth factor (VEGF), hormones that have considerable and diverse physiological importance, are thought to effect normal and exercise-induced hippocampal plasticity. Despite these predictions, relatively few published human studies have tested hypotheses that relate exercise and fitness to the hippocam

SUBMITTER: Whiteman AS 

PROVIDER: S-EPMC3991014 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature