TGF-beta1 gene polymorphism in association with diabetic retinopathy susceptibility: a systematic review and meta-analysis.

ABSTRACT:

Background

Transforming growth factor-beta (TGF-β1) gene has been regarded as an important mechanism in angiogenesis, endothelial cell proliferation, adhesion,and the deposition of extracellular matrix. The TGF-β1 gene may be involved in the development of diabetic retinopathy (DR) through disrupting angiogenesis. However, studies investigating the relationship between -509C/T and +869T/C(L10P) polymorphisms and DR yielded contradictory and inconclusive outcomes. In order to realize these ambiguous findings, a meta-analysis was performed to assess the association between the TGF-β1 gene polymorphisms and susceptibility to DR.

Methodology/principal findings

We conducted a search of all English reports on studies for the association between the TGF-β1 gene polymorphisms and su

SUBMITTER: Liu L 

PROVIDER: S-EPMC3991174 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature