Ontology highlight
ABSTRACT:
SUBMITTER: Afanasyeva A
PROVIDER: S-EPMC3991330 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Structure (London, England : 1993) 20140306 4
Eukaryotic TIP49a (Pontin) and TIP49b (Reptin) AAA+ ATPases play essential roles in key cellular processes. How their weak ATPase activity contributes to their important functions remains largely unknown and difficult to analyze because of the divergent properties of TIP49a and TIP49b proteins and of their homo- and hetero-oligomeric assemblies. To circumvent these complexities, we have analyzed the single ancient TIP49 ortholog found in the archaeon Methanopyrus kandleri (mkTIP49). All-atom hom ...[more]