Ontology highlight
ABSTRACT:
SUBMITTER: Attanasio C
PROVIDER: S-EPMC3991470 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20131001 6157
The shape of the human face and skull is largely genetically determined. However, the genomic basis of craniofacial morphology is incompletely understood and hypothesized to involve protein-coding genes, as well as gene regulatory sequences. We used a combination of epigenomic profiling, in vivo characterization of candidate enhancer sequences in transgenic mice, and targeted deletion experiments to examine the role of distant-acting enhancers in craniofacial development. We identified complex r ...[more]