Differential plasma proteome analysis in patients with high-altitude pulmonary edema at the acute and recovery phases.

ABSTRACT: This study aimed to investigate the differential expression of plasma proteins in patients suffering from high-altitude pulmonary edema (HAPE) at different phases. A complete proteomic analysis was performed using two-dimensional gel electrophoresis followed by mass spectrometry in three patients with HAPE at the acute stage and recovery phase. Comparisons between the expression patterns of the patients with HAPE at the two different phases led to the identification of eight protein spots with a >1.5-fold difference in expression between the acute and recovery phases. These differentially expressed proteins were apolipoproteins, serum amyloid P component, complement components and others. Apolipoprotein A-I (Apo A-I), serum amyloid P component and fibrinogen were overexpressed in the patie

SUBMITTER: Yang Y 

PROVIDER: S-EPMC3991535 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature