Ontology highlight
ABSTRACT:
SUBMITTER: Wu H
PROVIDER: S-EPMC3991565 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20140306 6179
The excitatory neurotransmitter glutamate induces modulatory actions via the metabotropic glutamate receptors (mGlus), which are class C G protein-coupled receptors (GPCRs). We determined the structure of the human mGlu1 receptor seven-transmembrane (7TM) domain bound to a negative allosteric modulator, FITM, at a resolution of 2.8 angstroms. The modulator binding site partially overlaps with the orthosteric binding sites of class A GPCRs but is more restricted than most other GPCRs. We observed ...[more]