Analysis of volatile compounds in exhaled breath condensate in patients with severe pulmonary arterial hypertension.

ABSTRACT:

Background

An important challenge to pulmonary arterial hypertension (PAH) diagnosis and treatment is early detection of occult pulmonary vascular pathology. Symptoms are frequently confused with other disease entities that lead to inappropriate interventions and allow for progression to advanced states of disease. There is a significant need to develop new markers for early disease detection and management of PAH.

Methodolgy and findings

Exhaled breath condensate (EBC) samples were compared from 30 age-matched normal healthy individuals and 27 New York Heart Association functional class III and IV idiopathic pulmonary arterial hypertenion (IPAH) patients, a subgroup of PAH. Volatile organic compounds (VOC) in EBC samples were analyzed using gas chromatography/mass spectrome

SUBMITTER: Mansoor JK 

PROVIDER: S-EPMC3991617 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature