Association of the catechol-O-methyltransferase val158met polymorphism and anxiety-related traits: a meta-analysis.

ABSTRACT:

Objectives

The aims of this study were (i) to examine genotypic association of the catechol-O-methyltransferase (COMT) val158met polymorphism with anxiety-related traits with a meta-analysis; (ii) to examine sex and ethnicity as moderators of the association; and (iii) to evaluate whether the association differed by particular anxiety traits.

Methods

Association studies of the COMT val158met polymorphism and anxiety traits were identified from the PubMed or PsycInfo databases, conference abstracts, and listserv postings. Exclusion criteria were (a) pediatric samples, (b) exclusively clinical samples, and (c) samples selected for a nonanxiety phenotype. Standardized mean differences in anxiety between genotypes were aggregated to produce mean effect sizes across all available

SUBMITTER: Lee LO 

PROVIDER: S-EPMC3991696 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature