The phenotypic and genetic signatures of common musculoskeletal pain conditions.

ABSTRACT: Musculoskeletal pain conditions, such as fibromyalgia and low back pain, tend to coexist in affected individuals and are characterized by a report of pain greater than expected based on the results of a standard physical evaluation. The pathophysiology of these conditions is largely unknown, we lack biological markers for accurate diagnosis, and conventional therapeutics have limited effectiveness. Growing evidence suggests that chronic pain conditions are associated with both physical and psychological triggers, which initiate pain amplification and psychological distress; thus, susceptibility is dictated by complex interactions between genetic and environmental factors. Herein, we review phenotypic and genetic markers of common musculoskeletal pain conditions, selected based on their ass

SUBMITTER: Diatchenko L 

PROVIDER: S-EPMC3991785 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature