Cyclooxygenase metabolism mediates vasorelaxation to 2-arachidonoylglycerol (2-AG) in human mesenteric arteries.

ABSTRACT:

Objective

The vasorelaxant effect of 2-arachidonoylglycerol (2-AG) has been well characterised in animals. 2-AG is present in human vascular cells and is up-regulated in cardiovascular pathophysiology. However, the acute vascular actions of 2-AG have not been explored in humans.

Approach

Mesenteric arteries were obtained from patients receiving colorectal surgery and mounted on a myograph. Arteries were contracted and 2-AG concentration-response curves were carried out. Mechanisms of action were characterised pharmacologically. Post hoc analysis was carried out to assess the effects of cardiovascular disease/risk factors on 2-AG responses.

Results

2-AG caused vasorelaxation of human mesenteric arteries, independent of cannabinoid receptor or transient receptor potenti

SUBMITTER: Stanley CP 

PROVIDER: S-EPMC3992009 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature