British randomised controlled trial of AV and VV optimization ("BRAVO") study: rationale, design, and endpoints.

ABSTRACT:

Background

Echocardiographic optimization of pacemaker settings is the current standard of care for patients treated with cardiac resynchronization therapy. However, the process requires considerable time of expert staff. The BRAVO study is a non-inferiority trial comparing echocardiographic optimization of atrioventricular (AV) and interventricular (VV) delay with an alternative method using non-invasive blood pressure monitoring that can be automated to consume less staff resources.

Methods/design

BRAVO is a multi-centre, randomized, cross-over, non-inferiority trial of 400 patients with a previously implanted cardiac resynchronization device. Patients are randomly allocated to six months in each arm. In the echocardiographic arm, AV delay is optimized using the iterative

SUBMITTER: Whinnett ZI 

PROVIDER: S-EPMC3992145 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature