A histologic scoring system for prognosis of patients with alcoholic hepatitis.

ABSTRACT:

Background & aims

There is no histologic classification system to determine prognoses of patients with alcoholic hepatitis (AH). We identified histologic features associated with disease severity and created a histologic scoring system to predict short-term (90-day) mortality.

Methods

We analyzed data from 121 patients admitted to the Liver Unit (Hospital Clinic, Barcelona, Spain) from January 2000 to January 2008 with features of AH and developed a histologic scoring system to determine the risk of death using logistic regression. The system was tested and updated in a test set of 96 patients from 5 academic centers in the United States and Europe, and a semiquantitative scoring system called the Alcoholic Hepatitis Histologic Score (AHHS) was developed. The system was vali

SUBMITTER: Altamirano J 

PROVIDER: S-EPMC3992184 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature