Genome-wide association study of opioid dependence: multiple associations mapped to calcium and potassium pathways.

ABSTRACT:

Background

We report a genome-wide association study (GWAS) of two populations, African-American and European-American (AA, EA) for opioid dependence (OD) in three sets of subjects, to identify pathways, genes, and alleles important in OD risk.

Methods

The design employed three phases (on the basis of separate sample collections). Phase 1 included our discovery GWAS dataset consisting of 5697 subjects (58% AA) diagnosed with opioid and/or other substance dependence and control subjects. Subjects were genotyped with the Illumina OmniQuad microarray, yielding 890,000 single nucleotide polymorphisms (SNPs) suitable for analysis. Additional genotypes were imputed with the 1000 Genomes reference panel. Top-ranked findings were further evaluated in Phase 2 by incorporating informa

SUBMITTER: Gelernter J 

PROVIDER: S-EPMC3992201 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature