Genetic implication of a novel thiamine transporter in human hypertension.

ABSTRACT:

Objectives

This study coupled 2 strategies-trait extremes and genome-wide pooling-to discover a novel blood pressure (BP) locus that encodes a previously uncharacterized thiamine transporter.

Background

Hypertension is a heritable trait that remains the most potent and widespread cardiovascular risk factor, although details of its genetic determination are poorly understood.

Methods

Representative genomic deoxyribonucleic acid (DNA) pools were created from male and female subjects in the highest- and lowest-fifth percentiles of BP in a primary care population of >50,000 patients. The peak associated single-nucleotide polymorphisms were typed in individual DNA samples, as well as in twins/siblings phenotyped for cardiovascular and autonomic traits. Biochemical properti

SUBMITTER: Zhang K 

PROVIDER: S-EPMC3992204 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature