Mix and match: investigating heteromeric and heterotypic gap junction channels in model systems and native tissues.

ABSTRACT: This review is based in part on a roundtable discussion session: "Physiological roles for heterotypic/heteromeric channels" at the 2013 International Gap Junction Conference (IGJC 2013) in Charleston, South Carolina. It is well recognized that multiple connexins can specifically co-assemble to form mixed gap junction channels with unique properties as a means to regulate intercellular communication. Compatibility determinants for both heteromeric and heterotypic gap junction channel formation have been identified and associated with specific connexin amino acid motifs. Hetero-oligomerization is also a regulated process; differences in connexin quality control and monomer stability are likely to play integral roles to control interactions between compatible connexins. Gap junctions in oligo

SUBMITTER: Koval M 

PROVIDER: S-EPMC3992227 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature