Neuroimaging and genetic risk for Alzheimer's disease and addiction-related degenerative brain disorders.

ABSTRACT: Neuroimaging offers a powerful means to assess the trajectory of brain degeneration in a variety of disorders, including Alzheimer's disease (AD). Here we describe how multi-modal imaging can be used to study the changing brain during the different stages of AD. We integrate findings from a range of studies using magnetic resonance imaging (MRI), positron emission tomography (PET), functional MRI (fMRI) and diffusion weighted imaging (DWI). Neuroimaging reveals how risk genes for degenerative disorders affect the brain, including several recently discovered genetic variants that may disrupt brain connectivity. We review some recent neuroimaging studies of genetic polymorphisms associated with increased risk for late-onset Alzheimer's disease (LOAD). Some genetic variants that increase risk

SUBMITTER: Roussotte FF 

PROVIDER: S-EPMC3992278 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature