CD74: a new prognostic factor for patients with malignant pleural mesothelioma.

ABSTRACT:

Background

The pro-inflammatory cytokine migration inhibitory factor (MIF) and its receptor CD74 have been proposed as possible therapeutic targets in several cancers. We studied the expression of MIF and CD74 together with calretinin in specimens of malignant pleural mesothelioma (MPM), correlating their expression levels with clinico-pathologic parameters, in particular overall survival (OS).

Methods

Migration inhibitory factor, CD74, and calretinin immunoreactivity were investigated in a tissue microarray of 352 patients diagnosed with MPM. Protein expression intensities were semiquantitatively scored in the tumour cells and in the peritumoral stroma. Markers were matched with OS, age, gender, and histological subtype.

Results

Clinical data from 135 patients were a

SUBMITTER: Otterstrom C 

PROVIDER: S-EPMC3992494 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature