Prognostic impact of genomic instability in colorectal cancer.

ABSTRACT:

Background

The prognostic impact of an indication of chromosomal instability (CIN) is evaluated in a consecutive series of 952 colorectal cancer patients treated at Aker University Hospital, Norway, during 1993-2003. Microsatellite instability (MSI) in this case series has recently been reported and made it possible to find the co-occurrence and compare the prognostic significance of CIN and MSI.

Methods

Data sets for overall survival (OS; n=855) and time to recurrence (TTR; n=579) were studied. To reveal CIN we used automated image cytometry (ICM). Non-diploid histograms were taken as indicative of the presence of CIN. PCR-based measures of MSI in this material have already been described.

Results

As with MSI, CIN was found to be an independent predictor of early rel

SUBMITTER: Hveem TS 

PROVIDER: S-EPMC3992498 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature