ASC amino-acid transporter 2 (ASCT2) as a novel prognostic marker in non-small cell lung cancer.

ABSTRACT:

Background

ASC amino-acid transporter 2 (ASCT2) is a major glutamine transporter that has an essential role in tumour growth and progression. Although ASCT2 is highly expressed in various cancer cells, the clinicopathological significance of its expression in non-small cell lung cancer (NSCLC) remains unclear.

Methods

One hundred and four patients with surgically resected NSCLC were evaluated as one institutional cohort. Tumour sections were stained by immunohistochemistry (IHC) for ASCT2, Ki-67, phospho-mTOR (mammalian target of rapamycin), and CD34 to assess the microvessel density. Two hundred and four patients with NSCLC were also validated by IHC from an independent cohort.

Results

ASC amino-acid transporter 2 was expressed in 66% of patients, and was closely cor

SUBMITTER: Shimizu K 

PROVIDER: S-EPMC3992511 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature