Synthesis of a miniature lipoarabinomannan.
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ABSTRACT:
SUBMITTER: Gao J
PROVIDER: S-EPMC3992881 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Publications
Synthesis of a miniature lipoarabinomannan.
Gao Jian J Liao Guochao G Wang Lizhen L Guo Zhongwu Z
Organic letters 20140121 3
An analog of Mycobacterium tuberculosis lipoarabinomannan (LAM) has been synthesized containing the characteristic structures of all of its three major components; that is, a mannosylated phosphatidylinositol moiety, an oligomannan, and an oligoarabinan. A highly convergent strategy was developed that is applicable to the synthesis of other LAM analogs. The synthetic miniature LAM should be useful for various biological studies. ...[more]
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