Low levels of serum vitamin D3 are associated with autoimmune thyroid disease in pre-menopausal women.

ABSTRACT:

Background

Low serum vitamin D levels have been associated with several autoimmune diseases, but their association with thyroid autoimmunity is unclear. We evaluated the association of serum vitamin D levels with the prevalence of autoimmune thyroid disease (AITD).

Methods

Our cross-sectional study included subjects who underwent routine health checkups, which included assays of serum 25-hydroxy vitamin D3 [25(OH)D3] and anti-thyroid peroxidase antibody (TPO-Ab), as well as thyroid ultrasonography (US) between 2008 and 2012 at the Asan Medical Center. We defined AITD according to the levels of TPO-Ab and US findings.

Results

A total of 6685 subjects (58% male; 42% female) were enrolled for this study. Overall prevalence of TPO-Ab positivity and both TPO-Ab/US positivi

SUBMITTER: Choi YM 

PROVIDER: S-EPMC3993051 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature