Attenuation of intestinal inflammation in interleukin-10-deficient mice infected with Citrobacter rodentium.

ABSTRACT: Interleukin-10 (IL-10) curtails immune responses to microbial infection and autoantigens and contributes to intestinal immune homeostasis, yet administration of IL-10 has not been effective at attenuating chronic intestinal inflammatory conditions, suggesting that its immune functions may be context dependent. To gain a broader understanding of the importance of IL-10 in controlling mucosal immune responses to infectious challenges, we employed the murine attaching and effacing pathogen Citrobacter rodentium, which colonizes primarily the surfaces of the cecum and colon and causes transient mucosal inflammation driven by Th17 and Th1 T helper cells. Infection induced macrophage and dendritic cell production of IL-10, which diminished antibacterial host defenses, because IL-10-deficient mic

SUBMITTER: Dann SM 

PROVIDER: S-EPMC3993455 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature