Protective immunity against recurrent Staphylococcus aureus skin infection requires antibody and interleukin-17A.

ABSTRACT: Although many microbial infections elicit an adaptive immune response that can protect against reinfection, it is generally thought that Staphylococcus aureus infections fail to generate protective immunity despite detectable T and B cell responses. No vaccine is yet proven to prevent S. aureus infections in humans, and efforts to develop one have been hampered by a lack of animal models in which protective immunity occurs. Our results describe a novel mouse model of protective immunity against recurrent infection, in which S. aureus skin and soft tissue infection (SSTI) strongly protected against secondary SSTI in BALB/c mice but much less so in C57BL/6 mice. This protection was dependent on antibody, because adoptive transfer of immune BALB/c serum or purified antibody into either BALB/c

SUBMITTER: Montgomery CP 

PROVIDER: S-EPMC3993461 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature