Improved detection of bacterial central nervous system infections by use of a broad-range PCR assay.

ABSTRACT: A universal PCR assay for bacteria and fungi detected meningitis pathogens in 65% of 20 cerebrospinal fluid (CSF) samples from patients with suspected central nervous system (CNS) infections compared to a 35% detection rate by culture and/or microscopy methods. Thus, the PCR assay can improve the diagnosis rate of infective meningitis when standard methods provide a negative result.

SUBMITTER: Meyer T 

PROVIDER: S-EPMC3993695 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature